John Langenfeld Selected Research

Proteins (Proteins, Gene)

1/2019	Double-Humanized Mouse Model to Study Bone Morphogenetic Protein (BMP) Signaling in Tumor Xenografts.
1/2018	Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer.
4/2016	Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death.
10/2013	Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin.
5/2008	Mycoplasma infection transforms normal lung cells and induces bone morphogenetic protein 2 expression by post-transcriptional mechanisms.
9/2003	The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells.

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John Langenfeld Research Topics

Disease

12	Neoplasms (Cancer) 05/2022 - 09/2003
10	Lung Neoplasms (Lung Cancer) 05/2022 - 12/2005
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2019 - 03/2015
4	Carcinoma (Carcinomatosis) 01/2022 - 09/2003
1	Starvation 05/2022
1	Alzheimer Disease (Alzheimer's Disease) 05/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 05/2022
1	Obesity 05/2022
1	Glioblastoma (Glioblastoma Multiforme) 05/2022
1	Brain Neoplasms (Brain Tumor) 05/2022
1	Fistula 11/2020
1	Infections 01/2020
1	Pain (Aches) 01/2020
1	Human Influenza (Influenza) 01/2020
1	Esophageal Neoplasms (Esophageal Cancer) 06/2019
1	Neoplasm Metastasis (Metastasis) 04/2016
1	Diaphragmatic Hernia 10/2015
1	Wounds and Injuries (Trauma) 01/2014
1	Adenocarcinoma of Lung 05/2008
1	Mycoplasma Infections 05/2008

Drug/Important Bio-Agent (IBA)

12	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 05/2022 - 09/2003
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2003
4	Bone Morphogenetic Protein ReceptorsIBA 01/2019 - 01/2013
3	Small Interfering RNA (siRNA)IBA 05/2022 - 01/2013
2	Carboplatin (JM8)FDA LinkGeneric 06/2019 - 04/2016
1	LigandsIBA 05/2022
1	sepantroniumIBA 01/2022
1	AMP-Activated Protein KinasesIBA 01/2022
1	CaspasesIBA 01/2022
1	Apoptosis Inducing FactorIBA 01/2022
1	Phenformin (Fenformin)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	allogenic effect factor (AEF)IBA 11/2020
1	Narcotics (Narcotic Analgesics)IBA 01/2020
1	VaccinesIBA 01/2020
1	SqualeneIBA 01/2020
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2020
1	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 01/2020
1	X-Linked Inhibitor of Apoptosis ProteinIBA 11/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 06/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 04/2016
1	Metformin (Glucophage)FDA LinkGeneric 03/2015
1	NestinIBA 10/2013
1	Green Fluorescent ProteinsIBA 10/2013
1	Bone Morphogenetic Protein 2IBA 05/2008
1	RNA (Ribonucleic Acid)IBA 05/2008
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 12/2005
1	WortmanninIBA 12/2005
1	Phosphotransferases (Kinase)IBA 12/2005
1	Messenger RNA (mRNA)IBA 09/2003
1	Biological ProductsIBA 09/2003

Therapy/Procedure

5	Therapeutics 07/2019 - 07/2015
4	Radiotherapy 01/2021 - 07/2015
3	Immunotherapy 01/2021 - 07/2019
2	Drug Therapy (Chemotherapy) 05/2022 - 01/2018
1	Analgesia 01/2020
1	Length of Stay 01/2020
1	Nerve Block (Nerve Blocks) 01/2020
1	Intramuscular Injections 01/2020
1	Contraindications 01/2020
1	Thoracotomy 01/2020
1	Catheters 01/2020
1	Image-Guided Radiotherapy 09/2016
1	Induction Chemotherapy 04/2016
1	Chemoradiotherapy 04/2016
1	Esophagectomy 10/2015
1	Anesthesia 01/2014